45 postdoctoral research fellow jobs found in Boston, MA

Overview: The Qi laboratory at the Dana-Farber Cancer Institute is looking for exceptional Postdoctoral Fellows in cancer biology (qi lab website: qilab.dana-farber.org). The Qi lab studies gene regulatory pathways using the emerging discipline of chemical biology. Successful candidates will work with an interdisciplinary team of scientists including medicinal chemists, biochemists, computational biologists, and cancer biologists to develop novel inhibitors of chromatin modifying enzymes, such as methyltransferases, demethylases and bromodomains. The successful candidate will perform research that will help make fundamental insights to cancer biology using novel small molecule inhibitors to gain mechanistic understanding in cancer therapy. We expect that novel therapeutics for human clinical investigation will emerge directly from these efforts through academic/industry collaborations. The postdoctoral fellow will be affiliated with the Department of Cancer Biology at Dana-Farber...

The Freed-Pastor Lab, specializing in gastrointenstinal cancer research, is seeking a qualified Postdoctoral Fellow. The lab utilizes molecular biology, biochemistry, cell biology, and organism models to study stem cell biology, gene regulation, epigenetic regulation, genetic dependencies, and drug discovery. Genome-wide molecular analyses of human and murine models routinely executed in the lab include WES, WGS, RNA-seq, single-cell RNA-seq, CHIP-seq, ATAC-seq, CRISPR genetic screens, and drug compound screens. We utilize genetically-engineered, carcinogen-induced, nude xenograft, human and murine neoplastic organoid, and PDX mouse models to investigate the molecular mechanisms underlying gastrointestinal cancer development. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to...

A postdoctoral fellow position is available to join the Hill Laboratory (https://hilllab.dana-farber.org/) in the Department of Medical Oncology at Dana-Farber Cancer Institute. We are looking for an enthusiastic fellow to work on our existing and upcoming projects. Our group studies the way ovarian and endometrial cancers respond to therapy and how the entire tumor changes over time, especially with respect to DNA damage repair defects in the tumor cells. We utilize complex ex vivo models of these tumors containing a full complement of tumor and normal cells to understand drug response and tumor evolution in real time. We aim to more fully characterize how evolving DNA damage repair defects in tumors cells change the entire tumor response to different therapies and lead to complex mechanisms of therapy resistance; develop methods to combat this resistance; and utilize our findings to design and implement better treatments in these deadly forms of women’s cancer. Located in Boston...

OVERVIEW Aberrant cell state plasticity and impaired differentiation are critical features of colorectal cancer. By utilizing a multidisciplinary approach, we aim to design and develop the next generation of therapeutics that induce differentiation of colorectal cancer. The Sethi Laboratory is looking to recruit an exceptional postdoctoral fellow to join their dedicated, diverse and collaborative team. We seek a highly motivated, creative, collegial and diligent M.D., Ph.D., or M.D./Ph.D. postdoctoral scholar with a strong background in molecular and cellular biology. Preference will be given to candidates with experience in genetic screens (e.g. CRISPR), chromatin biology, mouse models, and single-cell transcriptomics. The Sethi Laboratory is in the divisions of Molecular and Cellular Oncology and Gastrointestinal Oncology in the Medical Oncology Department at Dana-Farber Cancer Institute and Harvard Medical School. We are part of the Cancer Program at the Broad Institute ,...

A Post-Doctoral position is available to join the Insco Laboratory in the Department of Medical Oncology at Dana-Farber Cancer Institute. We are looking for an enthusiastic scientist to join our team! This role offers an unusual opportunity to contribute to a new laboratory in a newly renovated lab space! The Insco Lab is working to find new therapies for melanoma, the most deadly type of skin cancer by modeling human genetics and discovering the mechanisms driving melanoma. We have an emerging interest in mucosal melanoma, a deadly subtype of melanoma.. We seek to utilize the functional in vivo genetics of zebrafish paired with single cell RNA sequencing to identify the cell intrinsic and extrinsic drivers of mucosal melanoma. The tumor microenvironment will be investigated using fluorescent reporters in these tumor models. Functional testing will be done in zebrafish and human melanoma cells. We aim to discover novel therapeutic approaches for high-risk melanoma subtypes. Located...

The Xin Zhou Lab at the Dana-Farber Cancer Institute and Harvard Medical School is seeking a dedicated postdoctoral fellow to join our team (https://zhou-lab.org/). This exceptional opportunity is tailored for early-career researchers who have a strong interest in chemical biology, protein and antibody design, and immune engineering. Successful applicants will contribute to pioneering ideas that are redefining these fields. At the Zhou lab, we prioritize fostering a nurturing, inclusive, diverse, and compassionate environment. Our focus is on the mentoring and development of emerging scientists. Our postdoctoral fellow benefits from dual appointments as Research Fellows in both the Department of Biological Chemistry and Molecular Pharmacology at Harvard Medical School and Cancer Biology at Dana-Farber Cancer Institute. As members of these two departments and the Harvard Medical School community, the Zhou lab team has access to extensive resources and actively participates in a...

The Losman Lab is seeking an enthusiastic bench-level scientist to join our project team. We are focused on developing preclinical models of leukemia and identifying novel targets and therapies for cancer drug development. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. We are seeking an enthusiastic bench-level scientist to join our project...

A postdoctoral position is available in the laboratory of Gordon Freeman in the Department of Medical Oncology at the Dana-Farber Cancer Institute, Harvard Medical School. The lab focuses on costimulatory and coinhibitory pathways, particularly the PD-L1/PD-1 and HHLA2/KIR3DL3 pathways. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The...

The Anderson lab at Dana-Farber Cancer Institute is seeking a motivated and talented post-doctoral fellow who will contribute to discovery and translational research. The major focus of this specific position will include a talented fellow who develops and executes biological assays, interpret the results, analyze the data, and support further research activities. The post-doctoral fellow will be affiliated with the Department of Medical Oncology at Dana-Farber Cancer Institute, Harvard Medical School. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved...

We are looking for a Postdoctoral Fellow with background and interest in machine learning and artificial intelligence generally, and in (medical) image processing specifically, to work on applications of deep learning and conventional image analysis techniques to medical images and text (i.e., multi-modal learning). The clinical focus of this Dana-Farber internally funded project entails methods to assist radiologists in detection and classification of various cancer-related pathologies and to assist radiologists in error reduction during image interpretation. We are a cancer-imaging focused multi-disciplinary research team composed of primarily Dana-Farber Cancer Institute (DFCI) and Brigham and Women's Hospital (BWH) faculty. DFCI and BWH are teaching hospitals affiliated with Harvard Medical School and located in the Longwood Medical Area in Boston, Massachusetts. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing...

The Segal Lab at the Dana-Farber Cancer Institute has an opening for a Postdoctoral Research Fellow in Cancer Neuroscience. The funded project addresses development and disorders of sensory neurons. We use approaches from molecular biology, genetics, cell biology and biochemistry to address how the axons of sensory neurons develop, and to understand axonal degeneration in hereditary neuropathy and chemotherapy-induced degeneration. Mouse models, sophisticated culture systems, and imaging techniques, including real time imaging, in vivo analysis, TIRFF, and confocal microscopy are a major component of our work. The lab provides a supportive, and rigorous environment, with a strong commitment to diversity and to training. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an...

The Hovestadt and Stegmaier Labs in the Department of Pediatric Oncology at Dana-Farber Cancer Institute (affiliations with Boston Children’s Hospital and the Broad Institute of MIT and Harvard) are seeking highly motivated applicants for a POSTDOCTORAL RESEARCH FELLOW position. Our labs study childhood cancers, including brain tumors, leukemias, and high-risk solid tumors. We aim to better understand tumor biology and identify new therapeutic targets using cutting-edge experimental and computational approaches. We are leading a highly collaborative project with the Broad Institute and St. Jude Children’s Research Hospital, known as the Pediatric Cancer Dependency Map Accelerator. Our goal is to systematically profile and screen the spectrum of high-risk cancers diagnosed in children using CRISPR-based and small-molecule approaches. The project is an extension of our previous work which generated a first-generation Pediatric Cancer Dependency Map (Dharia et al., Nature Genetics ,...

The Freedman laboratory at Dana-Farber Cancer Institute and Harvard Medical School studies how the noncoding genome contributes to cancer pathogenesis and progression. Our work is characterized by asking questions of biological and clinical significance and deploying the appropriate tools to rigorously test these hypotheses. We use a variety of molecular biology, statistical, genomic, and epigenomic approaches to understand cancer. If required, we develop novel technology. Our research is highly collaborative and includes laboratory investigators, clinical investigators, and computational biologists. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all...

The Dana-Farber Cancer Institute seeks a computational Postdoctoral Research Fellow under the Baca lab (https://bacalab.dana-farber.org/) and the Center for Functional Cancer Epigenetics (https://cfce.dana-farber.org/) to analyze epigenomic datasets generated from patient samples in order help advance efforts for precision cancer medicine. The candidate will lead collaborative projects, working closely alongside oncologist and cancer biologists in a multidisciplinary and intellectually stimulating environment. The candidate will be affiliated with Harvard Medical School and the Broad Institute and is expected to rapidly grow their skillset and portfolio of high-impact publications in a fast-paced, intellectually stimulating environment with some of the world’s top researchers and physicians. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of...

The Aguirre laboratory at Dana-Farber Cancer Institute and Harvard Medical School studies the genetics and biology of gastrointestinal (GI) cancers, particularly pancreatic cancer. We utilize variety of molecular biology and genomic approaches to understand GI cancer with three major focus areas: 1) Discovery and validation of the new therapeutic targets in GI cancers; 2) Investigating RAS biology and targeting in pancreatic cancer; and 3) Understanding the genetic and phenotypic subtypes of pancreatic cancer using single cell genomic and transcriptomic analysis of tumor biopsies and patient-derived organoid models. Research in the laboratory ranges from basic mechanistic investigation of cancer gene function or novel small molecule therapeutics to highly translational genomic and functional studies of patient-derived tissues from clinical trials. The Aguirre lab works collaboratively within the Dana-Farber Hale Center for Pancreatic Research (https://halecenter.dfci.harvard.edu/),...

The Raghavan Laboratory at the Dana-Farber Cancer Institute and Harvard Medical School is seeking a highly motivated, creative, collaborative, and dedicated M.D., Ph.D., or M.D./Ph.D. postdoctoral research scholar to join the group. The Raghavan lab investigates how tumor cell transcriptional states shape cancer cell behaviors, microenvironmental interactions, and therapeutic sensitivity and resistance, with a primary focus in pancreatic and biliary cancers. We apply a variety of techniques including single-cell sequencing of patient samples and cell models, patient-derived organoid culture, high throughput drug testing, and CRISPR engineering with the long-term goal of identifying new state- and context-specific cancer vulnerabilities. We work closely with clinicians in the Gastrointestinal Cancer Center at DFCI to combine clinical observations and patient-derived data with rigorous basic science investigation to identify impactful translational advances that ultimately improve...

Postdoctoral Research Fellow will work on independent research projects in computational cancer evolution directed by the lab’s Principal Investigator, Franziska Michor, PhD. The lab works on developing and validating computational biology and mathematical modeling strategies of tumor evolution, heterogeneity and treatment response, and eventually utilize these strategies to identify best therapeutic interventions. We investigate the treatment response of cancer cells and their microenvironment, develop novel computational approaches and mathematical frameworks describing the evolutionary dynamics of tumor progression and treatment response that are parameterized using the experimental systems and clinical data, and predict and validate optimum intervention strategies that will ultimately be implemented as prospective clinical trials. We also use bioinformatics pipelines and develop novel bioinformatics approaches to analyze data types such as single cell RNA sequencing data,...

Our group at Dana-Farber Cancer Institute is looking for an exceptional Postdoctoral Research Fellow to conduct research on COVID in the area humoral cross-reactivity to circulating coronaviruses and pan-coronavirus vaccines. The project will explore the hypothesis in two parts; 1), that prior immunity against circulating coronaviruses can result in the development of antibodies that cross-bind and neutralize both endemic coronavirus and SARS-CoV-2. Utilizing our large COVID-19 convalescent patient cohort in combination with a cohort collected pre-pandemic, the primary goal of this project is to provide evidence of these cross-reactive antibodies and to establish the molecular basis by which coronavirus cross immunity arises through the identification of common spike epitopes. 2), we have established a humanized mouse model that will allow us to develop mosaic spike based pan-coronavirus vaccines based on the above principles. We will analyze 10X genomics and LibraSeq to perform in...

Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. The Hormoz Lab at the Dana-Farber Cancer Institute and Harvard Medical School (https://hormoz.hms.harvard.edu/) seeks highly motivated and dedicated postdoctoral fellows. The Hormoz Lab uses systems and synthetic biology to understand cellular state transitions during development, directed...

Our group at Dana-Farber Cancer Institute and Harvard Medical School is a seeking motivated and talented scientist who will contribute to basic discovery and translational research in multiple myeloma. Utilizing state-of-the-art single cell genomic technologies, high throughput screens, and chemical biology, our goal is to identify and validate novel molecular and immune targets using both in vitro and in vivo models of myeloma and its microenvironment. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research...