2 x ray jobs found

Job Ref:JR-1849 Location:450 Brookline Ave, BOSTON, MA 02215 Category:Research Laboratory Employment Type:Full time Work Location:Onsite: 100% onsite Salary/Pay Rate:$47,500.00 - $51,300.00 per year Overview The Polizzi lab uses a mix of computational and experimental approaches to design and characterize ligand-binding proteins. We develop machine-learning techniques to compute the structures and sequences of proteins that bind to challenging small-molecule ligands. We then express these proteins in the lab and characterize them with biophysical and structural methods (see, e.g., Ashworth, Polizzi & DeGrado, Science 2024). We aim not only to unlock the design principles used by proteins for molecular recognition but also to make useful proteins for probing and manipulating biology. By designing de novo small-molecule-binding proteins, we can isolate the essential ingredients for protein molecular recognition events, obtain atomic-level control...

Job Ref:JR-92 Location:450 Brookline Ave, BOSTON, MA 02215 Category:Fellowships Employment Type:Full time Work Location:Boston Job Posting Location Salary/Pay Rate:$72,000.00 - $76,385.00 per year Overview The Fischer Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology lab that combines molecular biology, computational biology, structural biology and chemistry with various ‘Omics’ techniques such as proteomics to study the pathways and protein complexes involved in the regulation of protein abundance via the ubiquitin proteasome system that are often associated with human diseases, including cancer. The Fischer lab integrates structural biology, molecular biology and computational-guided approaches to address fundamental questions about the mechanistic principles that govern signaling through the ubiquitin proteasome system.  Our laboratory is based at Dana-Farber Cancer Institute in Longwood Center and is an affiliate of the...