7 jobs found

Dana-Farber Cancer Institute is seeking an experienced PhD-level scientist to join the antibody discovery and antibody-based therapeutics development-focused Lab for Antibody and Nanobody Phage Display and Discovery (LAUNCHPAD). A pre-clinical strategic center, LAUNCHPAD’s mission is to streamline “discovery to translation” of antibody-based immunotherapies for cancer. The role also offers the possibility to work closely with faculty in DFCI's Data Science department for ongoing computational professional development and collaboration. The LAUNCHPAD team works closely with academic partners to design experimental strategies to identify promising antibody ‘hits’ as well as engineering hits to generate potential therapeutics, e.g. bispecific and CAR T-cell immunotherapies. The candidate should be an exceptionally motivated individual with a passion for working in multidisciplinary teams to model, design, screen and engineer immunotherapy candidates and advance next-generation...

The Center for Patient-Derived Models (CPDM) at Dana-Farber Cancer Institute is seeking a highly motivated and experienced Senior Scientist/Associate Director to support and help lead operations of our state-of-the-art functional precision medicine and patient-derived modeling program. The successful candidate will play a key role in advancing functional precision oncology research through the development, validation, and application of live cell assays for patient derived cells, patient-derived xenograft (PDX), patient-derived cell lines (PDCL), patient-derived organoid (PDO), and other model systems. This role involves managing a large portfolio of models, biospecimens, and collaborative projects while driving innovation in functional precision medicine, multi-omics integration, and translational research. The ideal candidate will have deep expertise in cancer biology, organoid/PDX technologies, novel emerging functional precision medicine assays. They should have a proven track...

The Medical Technologist III is responsible for following procedures and performing tests on body fluids using automated analyzers and manual test procedures under minimal supervision, in accordance with laboratory procedures. The Medical Technologist III is responsible for adherence to the laboratory quality control policies and procedures to ensure reporting of accurate and timely test results. The Medical Technologist III will assist in the training of new personnel and carry out special assignments/projects for the department. In addition, the Medical Technologist III will assist with correlation studies, assessment of new instruments and materials. Position is 100% on-site. Required hours are 8:00 a.m. to 4:30 p.m., with rotating weekends. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related...

The Targeted Protein Degradation (TPD) Proteomics Core within the Fischer Lab at Dana-Farber Cancer Institute serves as a resource for the Cancer Biology Department, aiding investigators in answering key research questions using mass spectrometry-based proteomics. We employ quantitative chemoproteomic and interactomic approaches to identify drug targets and are continuing to expand our repertoire to meet the needs of our core users. Our core is equipped with extensive mass spectrometry equipment including timsTOF HT, timsTOF Ultra2 and Orbitrap Eclipse tribrid mass spectrometers. The TPD Core seeks a highly motivated individual to join the team as a RESEARCH SCIENTIST, who will employ mass spectrometry-based technologies to assess the cellular proteome in response to external stimuli. This individual will be an important member of our core team and will work across a variety of different research projects focused on targeted protein degradation as a novel therapeutic modality....

The Department of Data Science at the Dana-Farber Cancer Institute (DFCI) seeks candidates with a strong background in biostatistics, machine learning, and/or computational biology to collaborate with researchers at the Hale Family Center for Pancreatic Cancer Research. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical...

The Lab Manager role is responsible for facilitating a senior faculty member’s research program through management of the laboratory operations and specifically the management of grant timelines, lab deliverables, and collaborations with other entities. Responsibility will include assistance with PI’s administrative responsibilities in the laboratory and supervision of technical staff to manage and maintain good laboratory practice. This individual will report to the Associate Director of the Center for Early Detection and Interception of Blood Cancers and the PI and work closely with PI’s management team. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS, and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of...

The Fischer Lab at Dana-Farber Cancer Institute is a Structural and Chemical Biology lab that combines molecular biology, computational biology, structural biology and chemistry with various ‘Omics’ techniques such as proteomics to study the pathways and protein complexes involved in protein homeostasis and the ubiquitin proteasome system often associated with human diseases, including cancer. The Fischer lab integrates structural biology, molecular biology and computational guided approaches to address fundamental questions about the mechanistic principles that govern signaling through the ubiquitin proteasome system. The Fischer Lab (https://fischerlab.org/) seeks a highly motivated individual to join the research team as a Cryo-EM SCIENTIST who will work on various structural biology and biochemical projects addressing fundamental questions in our understanding of the ubiquitin system and ways we can manipulate this system with molecular glues and degrader molecules for...