66 scientist jobs found in Boston, MA

Dana-Farber Cancer Institute is seeking an experienced PhD-level scientist to join IMPACT, a new pre-clinical research group with the mission to streamline “discovery to translation” of antibody-based immunotherapies for cancer. The IMPACT team will work closely with DFCI PIs as well as external academic and industry partners to design experimental strategies to identify promising antibody ‘hits’ as well as engineering hits to generate potential therapeutic bispecific and CAR T-cell immunotherapies. The candidate should be an exceptionally motivated individual with a passion for working in multidisciplinary teams to design, screen and engineer immunotherapy candidates and advance next-generation therapies. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive,...

POSITION SUMMARY: The Artificial Intelligence & Machine Learning Engineer/Scientist II works within the Artificial Intelligence Operations and Data Science Services group (AIOS) in the Informatics & Analytics department of Dana-Farber Cancer Institute – a teaching affiliate of Harvard Medical School. The Artificial Intelligence & Machine Learning Engineer/Scientist II works in a team environment on both short-term priorities identified by our top clinicians, as well as on long-term institutional efforts that aim at revolutionizing the way the Institute conducts basic cancer research and provides best-in-class clinical oncology to our patients. AIOS is part of the department serving some of the most prominent research and clinical programs at the Institute, from basic to translational research, to clinical deployment, and operationalization. The AIOS group encompasses expertise in AI, data science, machine learning, computer vision, NLP, production deployment, cloud...

POSITION SUMMARY: The Center for Patient Derived Models (CPDM) at DFCI is seeking applicants for the position of Research Scientist I. This is an exciting new initiative at the DFCI which seeks to advance modeling science and research using patient derived cell lines (PDCL), patient derived organoids (PDO), patient derived xenografts (PDX), and patient cells in functional precision medicine (FPM) studies. Applicants must have prior experience in laboratory research and preclinical studies in both in vitro and in vivo methods. The applicant will work to advance our knowledge of precision medicine, cancer biology, treatment and diagnostics in all cancer types of adults and children. Applicants hired to this position will apply modern cutting-edge techniques to study and create patient derived models of cancer. Collaborations and projects involve direct interaction with academic and biopharma industry partners. Located in Boston and the surrounding communities, Dana-Farber Cancer...

The Targeted Protein Degradation (TPD) Proteomics Core within the Fischer Lab at Dana-Farber Cancer Institute serves as a resource for the Cancer Biology Department, aiding investigators in answering key research questions using mass spectrometry-based proteomics. We employ quantitative chemoproteomic and interactomic approaches to identify drug targets and are continuing to expand our repertoire to meet the needs of our core users. The TPD Core seeks a highly motivated individual to join the team as a Research Scientist who will focus on mass spectrometry-based technologies to assess the cellular proteome in response to external stimuli. This individual will be an important member of our core team and will work with technicians, scientists, postdocs and students on a variety of different research projects focused on targeted protein degradation as a novel therapeutic modality. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute brings together...

We are seeking a COMPUTATIONAL STAFF SCIENTIST who will join the teams of Dr. Mariella Filbin in the Department of Pediatric Oncology at the Dana-Farber Cancer Institute. Our goal is to develop new therapeutic approaches for children brain tumors by overcoming “differentiation blocks” in cancer cells. Specifically, our research focuses on understanding the genetic and epigenetic changes that lock cancer cells in a stem-like state, preventing differentiation into normal cells. The successful candidate will collaborate closely with other scientists across the Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive...

The laboratory of Zuzana Tothova, MD, PhD is a multi-disciplinary team of physician scientists, scientists and computational biologists at the Dana-Farber Cancer Institute. Our laboratory uses genomics and a range of molecular and cellular biological techniques to elucidate the molecular basis of cancer and hematologic disorders and to develop novel therapeutics. Our specific focus is to understand the role of chromatin modifiers and epigenetic factors and find novel therapeutic opportunities in myeloid malignancies, including myelodysplastic syndromes and acute myeloid leukemia. A full-time Staff scientist position is available in the laboratory of Zuzana Tothova, MD, Ph.D. at Dana-Farber Cancer Institute. Visit our website at: https://tothovalab.dana-farber.org/ We are seeking enthusiastic, self-motivated individuals who thrive in a fast-paced, challenging research environment, and can interact well with others as part of a cohesive team. If you have a desire to make a...

The Bandopadhayay Lab (www.bandolab.org) at DFCI (with co-affiliations with Boston Children’s Hospital and the Broad Institute) is seeking a Research Scientist to join our efforts to find better treatments for children with brain tumors. We apply cutting-edge genomic technologies to identify drivers of childhood cancers, identify strategies to target these and to determine mechanisms of resistance to current and novel treatments. The aim of these efforts is to perform translational research to develop new therapies to improve outcomes of children diagnosed with these tumors. The work will be highly translational and span efforts from profiling the cancer genomes of pediatric brain tumors to determining new therapeutic targets, applying molecular oncology and functional genomic methodologies to determine oncogenic mechanisms and identify new dependencies, and to characterize mechanisms of resistance. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute...

Bioinformatics and Molecular Data team is a growing group at the Informatics and Analytics Department (I&A) of Dana-Farber Cancer Institute (DFCI). The team addresses unmet needs for bioinformatics, data management, data mining and analysis across research, clinical, and operational units. It accelerates use of bioinformatics and data science methods, data, and tools within DFCI, bridging the gap between research and clinical practice and helping design and implement operational solutions. The group encompasses expertise in bioinformatics, data science, machine learning, and software engineering. It works with some of the most prominent research and clinical DFCI programs, from basic research to translational research, to clinical diagnostics and operations. We look for an intelligent, hard-working, and dynamic individual to fill the role of Bioinformatics Scientist in the team. The successful candidate will support key initiatives relying on genomic data, have the ability to...

POSITION SUMMARY: The Artificial Intelligence & Machine Learning Engineer/Scientist I works within the Artificial Intelligence Operations and Data Science Services group (AIOS) in the Informatics & Analytics department of Dana-Farber Cancer Institute – a teaching affiliate of Harvard Medical School. The Artificial Intelligence & Machine Learning Engineer/Scientist I works in a team environment on both short-term priorities identified by our top clinicians, as well as on long-term institutional efforts that aim at revolutionizing the way the Institute conducts basic cancer research and provides best-in-class clinical oncology to our patients. AIOS is part of the department serving some of the most prominent research and clinical programs at the Institute, from basic to translational research, to clinical deployment, and operationalization. The AIOS group encompasses expertise in AI, data science, machine learning, computer vision, NLP, production deployment, cloud...

The Viswanathan lab at the Dana-Farber Cancer Institute uses genomic and cutting-edge genome-scale functional genetic technologies to uncover drivers of genitourinary malignancies, with a specific focus on prostate and kidney cancers. We are in search of a highly motivated and experienced Research Technician / laboratory manager to join the Viswanathan laboratory. The projects will involve mechanistic study of genitourinary cancers (specifically kidney cancer) with the goal of developing insights that can be translated into novel therapeutics and improved outcomes for patients with these cancers. Responsibilities will include carrying out a research project related to the pathogenesis of kidney cancer under the close mentorship of senior postdoctoral fellows/staff and the principal investigator. In addition, there will be responsibilities related to lab management/administration, including maintenance of laboratory equipment and reagent inventories and reagent ordering, as...

The Center for Cancer Systems Biology (CCSB) at the Dana-Farber Cancer Institute has an immediate opening for a Research Support Technician to join a team of scientists and staff characterizing genomic variations in human disease genes by assisting in executing experimental protocols and procedures under the direction of lab manager or research scientist. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing...

A Post-Doctoral position is available to join the Insco Laboratory in the Department of Medical Oncology at Dana-Farber Cancer Institute. We are looking for an enthusiastic scientist to join our team! This role offers an unusual opportunity to contribute to a new laboratory in a newly renovated lab space! The Insco Lab is working to find new therapies for melanoma, the most deadly type of skin cancer by modeling human genetics and discovering the mechanisms driving melanoma. We have an emerging interest in mucosal melanoma, a deadly subtype of melanoma.. We seek to utilize the functional in vivo genetics of zebrafish paired with single cell RNA sequencing to identify the cell intrinsic and extrinsic drivers of mucosal melanoma. The tumor microenvironment will be investigated using fluorescent reporters in these tumor models. Functional testing will be done in zebrafish and human melanoma cells. We aim to discover novel therapeutic approaches for high-risk melanoma subtypes. Located...

The Losman Lab is seeking an enthusiastic bench-level scientist to join our project team. We are focused on developing preclinical models of leukemia and identifying novel targets and therapies for cancer drug development. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research that advances treatment, we educate tomorrow's physician/researchers, and we work with amazing partners, including other Harvard Medical School-affiliated hospitals. We are seeking an enthusiastic bench-level scientist to join our project...

The Oser Laboratory in the Division of Molecular and Cellular Oncology and the Department of Medical Oncology at the Dana-Farber Cancer Institute/Harvard Medical School focuses on identifying new therapeutic targets in small cell lung cancer (SCLC). SCLC is a highly aggressive neuroendocrine cancer that is driven by loss of function (LOF) mutations in the tumor suppressor genes RB1, TP53, and NOTCH. It is also characterized by high expression of oncogenic neural/neuroendocrine transcription factors including ASCL1, NEUROD1, and POU2F3, which are dependencies in SCLC, but are undruggable. Our lab utilizes several approaches including CRISPR/Cas9-based functional screening and developing genetically-engineered mouse models of SCLC using CRISPR/Cas9 to identify novel ways to target LOF mutations in tumor suppressor genes and undruggable oncogenic drivers. Through our research, we seek to gain a more comprehensive understanding of SCLC tumorigenesis and identify new targeted therapy...

Senior Research Associate, in vivo Rewarding science, cutting edge technology, and a diverse and collaborative work environment. The integration of basic and translational research at the Belfer Center provides a unique opportunity to advance therapies to prolong the lives of cancer patients. As part of our growing team, we are seeking highly motivated and experienced scientist for our in vivo team. We have a creative and collegial culture that supports the professional development of our people. For more information please visit: http://belfercenter.dfci.harvard.edu Publications here: https://belfercenter.dfci.harvard.edu/publications/ Assist with the establishment and maintenance of mouse cancer models (e.g. by injection or minor / major surgery). Build of syngeneic, xenograft, PDX and orthotopic mouse cancer models Perform mouse in vivo animal procedures, including dosing animals by various routes (e.g. oral, intravenous, intraperitoneal, etc), measuring tumors by calipers,...

Our group at Dana-Farber Cancer Institute and Harvard Medical School is a seeking motivated and talented scientist who will contribute to basic discovery and translational research in multiple myeloma. Utilizing state-of-the-art single cell genomic technologies, high throughput screens, and chemical biology, our goal is to identify and validate novel molecular and immune targets using both in vitro and in vivo models of myeloma and its microenvironment. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to patients of all backgrounds, and design programs to promote public health particularly among high-risk and underserved populations. We conduct groundbreaking research...

The laboratory of Benjamin Ebert, MD, Ph.D. is seeking a full-time technical research associate for a position at Dana-Farber Cancer Institute. (https://ebertlab.dana-farber.org/ ) Our lab uses a range of genomic, molecular, and cellular biological techniques to elucidate the molecular basis of cancer and hematologic disorders and to develop novel therapeutic possibilities. We focus our efforts on determining the genetic drivers that result in myeloid malignancies and potentiate pre-malignant states in blood cancers. We seek an enthusiastic, and self-motivated individual who thrives in a fast-paced and challenging research environment. The candidate should feel comfortable as a part of an inclusive, diverse, and cohesive team. You should be able to draw on experience and skill to contribute to experimental design and execution, operation of laboratory instruments to conduct experiments, make scientific observations and record results, and use various analysis methods to determine...

The Computational Biologist I is responsible for routine data analysis or processing of biological data, with a focus on high-throughput technologies and genomic databases. The Computational Biologist is a quantitative scientist who collaborates with scientific investigators and with other research staff in the analysis of high-throughput data, and dissemination of scientific results. The Computational Biologist may work on many types of projects and areas of research including cancer genomics, functional genomics, immuno-oncology, molecular imaging, data management and integration, and querying biological databases. Located in Boston and the surrounding communities, Dana-Farber Cancer Institute is a leader in life changing breakthroughs in cancer research and patient care. We are united in our mission of conquering cancer, HIV/AIDS and related diseases. We strive to create an inclusive, diverse, and equitable environment where we provide compassionate and comprehensive care to...

The Aguirre lab at Dana-Farber Cancer Institute is a basic and translational oncology laboratory with a focus on gastrointestinal cancers, such as pancreatic cancer. We utilize a variety of genomic, functional genetic and molecular biology approaches to identify novel therapeutic strategies in pancreatic cancer and to test these strategies in patient-derived models or genetically engineered mouse models of the disease. We actively collaborate with clinical oncologists, surgeons, pathologists, geneticists and computational biologists to perform multi-disciplinary translational research. We are in search of a highly motivated and capable Senior Research Technician to join the Aguirre lab at Dana-Farber Cancer Institute to work with both animal models and organoid of pancreatic cancer and to test new therapeutic strategies in these models. The successful candidate will have a strong interest in cancer biology and therapeutics and will function as part of a multidisciplinary basic...

The Dana-Farber Cancer Institute's Center for Immuno-Oncology (DFCI CIO) is recruiting a Pathologist/Histopathologist to perform pathology review, interpretation and analysis of research projects in the CIO Tissue Biomarker Laboratory. The CIO’s goals are to support the conduct of human-based immuno-oncology research and develop innovative approaches and technologies. As part of the Center, the Tissue Biomarker Laboratory performs quantitative and qualitative assessment of Immune Biomarkers, and supports DFCI research projects by performing multiplex quantitative immune-staining and image analysis, as well as other research analyses such as chromogenic immunohistochemical (IHC) staining, targeted gene expression profiling and molecular classification, targeted genetic and genomic analyses (FISH). The Tissue Biomarker Laboratory employs 2 Ph.D. scientists and 5 technicians and is involved in 10-12 collaborative research projects at any given time. A critical component of all...